ZEB1

4 papers2 findings

HGNC NCBI Gene Taxon

2 independent labs in 2 countries

Funders: Centre Léon Bérard and 5 more

Humans1
Animals2
Cells1

Effects

1

Epithelial-to-mesenchymal plasticity

upin human cells1

1 study

ZEB1 increases epithelial-to-mesenchymal plasticity in human cells.
“oncogenic activation of RAS promotes ZEB1-dependent EMP, which is necessary for malignant transformation”
Cellsin inducible human mammary epithelial cells
Cooperative pro-tumorigenic adaptation to oncogenic RAS through epithelial-to-mesenchymal plasticity
Science advances14 Feb 2024

Upstream

1

FBN1

upin mice1

1 study

FBN1 increases ZEB1 in mice.
“FBN1 upregulates the transcription factor ZEB1, which binds to the EDN1 promoter to enhance endothelin-1 (ET-1) transcription”
Animalskidney endothelium
Fibrillin-1 Orchestrates a Pro-senescent Niche Driving Peritubular Endothelial Senescence via ZEB1/endothelin-1/β-catenin Signaling
International journal of biological sciences29 May 2026

Latest

3 in 12 months

International Journal of Nanomedicine24 Jun

Comparable Efficacy of Chitosan/miR-200b-3p and Lipofectamine/miR-200b-3p Delivered by Pluronic F127 Hydrogel to Facilitate Diabetic Wound Healing

Experiments in miceSkin

International Journal of Biological Sciences22 Jun

Fibrillin-1 Orchestrates a Pro-senescent Niche Driving Peritubular Endothelial Senescence via ZEB1/endothelin-1/β-catenin Signaling

Experiments in miceCellular senescence

AAIC 2025 Abstract24 Dec

Environment‐susceptible genetic loci for imaging‐based preclinical markers of ADRD, and the influence of modifiable risk factors

Cohort study of 45,275 peopleMechanisms

Science Advances14 Feb

Cooperative pro-tumorigenic adaptation to oncogenic RAS through epithelial-to-mesenchymal plasticity

Experiments in human cellsMechanisms