ZDHHC5

1. ZDHHC5 protects against neurodegeneration in mice.

   “which exaggerates neurodegeneration in an autophagy-dependent manner.”

   Animalsin an autophagy-dependent manner in Alzheimer's disease models

   Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging

   Nature structural & molecular biology·4 Jan 2024

1. ZDHHC5 decreases proteostasis in mice.

   “We show that DHHC5 deficiency in neurons leads to reduced cellular protein homeostasis in two established murine models of Alzheimer's disease”

   Animalsin neurons in Alzheimer's disease models

   Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging

   Nature structural & molecular biology·4 Jan 2024

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