What does the research say about USP46?

USP46

There are 2 papers on USP46 in aging research: none in people yet, 2 in animals. The newest story, Nov 9, 2026: “Particles from exercised muscle reduced heart injury in mice”.

Gene

2 papers study it2 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 2 papers on USP46

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“Patients with DN have lower expression of USP46 in podocytes, which is linked to higher proteinuria.”

Acarbose ameliorates podocyte injury and glomerular lesions in diabetic nephropathy through USP46 activationScience translational medicine2026doi:10.1126/scitranslmed.ads4585

None of its findings points the other way.

1 lab in 1 country

Funders: National Key Research and Development Program of China and 1 more

Animals2

Interventions

Acarbose

upin cells1

1 study

Acarbose activates USP46 in cells.
“we identified acarbose as an agonist of USP46”
Cellspodocyte
Acarbose ameliorates podocyte injury and glomerular lesions in diabetic nephropathy through USP46 activation
Science translational medicineMar 11, 2026

Associations

Proteinuria

upin humans1

1 study

USP46 is associated with proteinuria in humans (diabetic nephropathy patients).
“Patients with DN have lower expression of USP46 in podocytes, which is linked to higher proteinuria.”
Humansdiabetic nephropathy patientspodocyte
Acarbose ameliorates podocyte injury and glomerular lesions in diabetic nephropathy through USP46 activation
Science translational medicineMar 11, 2026

Latest

2 papers in 12 months

Circulation ResearchNov 9

Particles from exercised muscle reduced heart injury in mice

Mouse experiments tracked tiny packages released by skeletal muscle after four weeks of exercise and tested their role in limiting heart damage.Mouse experiments tracked tiny packages released by skeletal muscle after four weeks of exercise and tested their role in limiting heart damage.

Mouse studyExercise