TSA1

1. TSA1 improves recovery upon nutrient repletion in yeast cells.

   “resulting in abnormally small cells that contribute to the reduced chronological lifespan and delayed recovery upon nutrient repletion.”

   CellsAfter glucose depletion; shown by TSA1 deletion

   The peroxiredoxin Tsa1 promotes stationary phase entry by suppressing PKA activity

   bioRxiv (Cold Spring Harbor Laboratory)·26 Nov 2025Preprint

1. TSA1 extends chronological lifespan in yeast cells.

   “resulting in abnormally small cells that contribute to the reduced chronological lifespan and delayed recovery upon nutrient repletion.”

   CellsGlucose depletion; shown by TSA1 deletion and failure to attenuate PKA activity

   The peroxiredoxin Tsa1 promotes stationary phase entry by suppressing PKA activity

   bioRxiv (Cold Spring Harbor Laboratory)·26 Nov 2025Preprint

1. TSA1 increases storage carbohydrate accumulation in yeast cells.

   “Consequently, tsa1 Δ cells display delayed transition to respiratory growth, reduced gluconeogenic capacity, and impaired accumulation of storage carbohydrates.”

   CellsUpon glucose depletion; shown by TSA1 deletion

   The peroxiredoxin Tsa1 promotes stationary phase entry by suppressing PKA activity

   bioRxiv (Cold Spring Harbor Laboratory)·26 Nov 2025Preprint

1. TSA1 improves transition to respiratory growth in yeast cells.

   “Consequently, tsa1 Δ cells display delayed transition to respiratory growth, reduced gluconeogenic capacity, and impaired accumulation of storage carbohydrates.”

   CellsUpon glucose depletion; shown by TSA1 deletion

   The peroxiredoxin Tsa1 promotes stationary phase entry by suppressing PKA activity

   bioRxiv (Cold Spring Harbor Laboratory)·26 Nov 2025Preprint

1. TSA1 inhibits PKA signaling in yeast cells.

   “we show that loss of Tsa1 leads to incomplete downregulation of PKA signaling.”

   CellsDuring glucose depletion and stationary phase entry; shown by TSA1 deletion

   The peroxiredoxin Tsa1 promotes stationary phase entry by suppressing PKA activity

   bioRxiv (Cold Spring Harbor Laboratory)·26 Nov 2025Preprint

1. TSA1 decreases rDNA recombination frequency in yeast cells.

   “Tsa1 deficiency led to lower replication initiation and an elevated recombination frequency in the rDNA.”

   Cellsshown by Tsa1 deficiency

   The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster

   bioRxiv (Cold Spring Harbor Laboratory)·14 Mar 2024Preprint

More on rDNA recombination frequency

1. TSA1 increases replication initiation in yeast cells.

   “Tsa1 deficiency led to lower replication initiation and an elevated recombination frequency in the rDNA.”

   Cellsshown by Tsa1 deficiency

   The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster

   bioRxiv (Cold Spring Harbor Laboratory)·14 Mar 2024Preprint

1. TSA1 decreases rDNA instability in yeast cells.

   “Here we demonstrate that Tsa1 is required for stabilizing the ribosomal RNA gene (rDNA) cluster.”

   Cellsshown by Tsa1 deficiency

   The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster

   bioRxiv (Cold Spring Harbor Laboratory)·14 Mar 2024Preprint

1. TSA1 extends lifespan in yeast cells.

   “The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster”

   Cellsin budding yeast

   The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster

   bioRxiv (Cold Spring Harbor Laboratory)·14 Mar 2024Preprint