TPP2

1. TPP2 inhibits inflammation in mice.

   “accelerated thymic involution, lymphopenia, impaired proliferative T cell responses, extramedullary hematopoiesis, and inflammation”

   Animalsshown by knockout

   Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice

   Proceedings of the National Academy of Sciences of the United States of America·24 Mar 2008

More on Inflammation

1. TPP2 inhibits cellular senescence in mice.

   “premature cellular senescence in fibroblasts and CD8(+) T cells”

   Animalsshown by knockout

   Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice

   Proceedings of the National Academy of Sciences of the United States of America·24 Mar 2008

More on Cellular senescence

1. TPP2 inhibits apoptosis in mice.

   “TPPII deficiency activates cell type-specific death programs, including proliferative apoptosis in several T lineage subsets”

   Animalsshown by knockout

   Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice

   Proceedings of the National Academy of Sciences of the United States of America·24 Mar 2008

More on Apoptosis