TINF2

1 paper3 findings

HGNC MGI NCBI Gene Taxon

1 lab in 1 country

Funders: National Natural Science Foundation of China and 1 more

Humans1

Effects

3

Cellular senescence

upin human cells1

1 study

TINF2 induces cellular senescence in human cells.
“increased senescence-associated β-galactosidase activity”
Cellsin HEK293T cells overexpressing mutant vs wild-type TINF2
Suspected parental gonadal/gonadosomatic mosaicism for a TINF2 mutation in two sisters with dyskeratosis congenita
Frontiers in genetics15 Jul 2026

More on Cellular senescence

Telomere length

downin human cells1

1 study

TINF2 decreases telomere length in human cells.
“a reduced relative telomere length signal (P < 0.001)”
Cellsin HEK293T cells overexpressing mutant vs wild-type TINF2
Suspected parental gonadal/gonadosomatic mosaicism for a TINF2 mutation in two sisters with dyskeratosis congenita
Frontiers in genetics15 Jul 2026

More on Telomere length

Cell proliferation

downin human cells1

1 study

TINF2 impairs cell proliferation in human cells.
“decreased cellular proliferation suggestive of impaired proliferative capacity”
Cellsin HEK293T cells overexpressing mutant vs wild-type TINF2
Suspected parental gonadal/gonadosomatic mosaicism for a TINF2 mutation in two sisters with dyskeratosis congenita
Frontiers in genetics15 Jul 2026

Latest

1 in 12 months

Frontiers in Genetics16 Jul

Suspected parental gonadal/gonadosomatic mosaicism for a TINF2 mutation in two sisters with dyskeratosis congenita

Case series of 2 peopleMechanisms