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1 paper

Model organisms1

Latest

Aging·26 Jun

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Experiments in fliesInterventions

Related

AMPK signalling1
ATP/ADP ratio1
Autophagy1
Circadian clock1
FOXO signalling1
HDAC41
Heat shock response and chaperones1
Hnf41
Hsp221
Hsp701
Lipid and ceramide metabolism1
Oxidative stress and ROS signalling1
PI3K–AKT signalling1
Pi3K92E1
SIRT11
SNF4A1

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ER-100 glaucoma trial findings support testing higher dosesTrialsLongevity.Technology and 4 more

New immune cell map reveals how individual immune aging trajectories divergeResearchMedical Xpress and 2 more

Newer cohorts of older Europeans show slower intrinsic capacity lossResearchThe Lancet Healthy Longevity

Trials

AKG and Brain Health in AgingPhase 2Registered 6 Oct 2026, University of Oklahoma Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)Phase 1Registered 2 Oct 2026, Vinmec Research Institute of Stem Cell and Gene Technology AI-Based Conversational Social Support for Older Adults With Heart FailureRegistered 7 Oct 2026, Chang Gung University of Science and Technology

Trending

Nicotinamide ribosideInterventionNicotinamide riboside did not improve early Parkinson disease PregnancyExposureEstimated brain-age gap rises by three years in pregnancy TERTGeneBlood-cell telomerase delays premature aging in zebrafish Vitamin DInterventionSevere vitamin D deficiency is linked to higher death rates TMEM174GeneTMEM174 deficiency shortens lifespan and stiffens vessels in mice Ketogenic dietInterventionKetogenic diet improved heart function in aged mice

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