SLIT2
- 1 lab in 1 country
- Funder: NHLBI Division of Intramural Research
- Human trial1
- Humans1
Effects
1Canonical Th17 polarization
downin human cells1
1 study
Canonical Th17 polarization
downin human cells1
SLIT2 decreases canonical Th17 polarization in human cells.
“SLIT2, acting through the ROBO1 receptor, inhibited Rho GTPase signaling, thereby attenuating canonical Th17 polarization and fibroblast inflammatory activation.”
Cellsin CD4+ T cells and fibroblasts
JCI insight28 Apr 2026
Latest
1 in 12 monthsJCI Insight
NAD+ augmentation by nicotinamide riboside engages SLIT2/ROBO1 signaling to attenuate Th17 inflammation in psoriasis
Randomised trial in peopleNicotinamide riboside