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SLC12A8

Gene

3 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Biotechnology and Biological Sciences Research Council and 4 more
  • Animals3

Effects

2

NAD+

upin mice1

1 study

  1. SLC12A8 increases NAD+ in mice.

    “Slc12a8 deficiency significantly decreases NAD+ levels in the jejunum and ileum”

    Animalsshown by Slc12a8 deficiencyjejunum and ileum

    Slc12a8 is a nicotinamide mononucleotide transporter

    Nature metabolism

More on NAD+

NMN uptake

is required forin mice1

1 study

  1. SLC12A8 is required for NMN uptake in mice.

    “Slc12a8 knockdown abrogates the uptake of NMN in vitro and in vivo.”

    Animalsshown by Slc12a8 knockdown

    Slc12a8 is a nicotinamide mononucleotide transporter

    Nature metabolism

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