SLC12A8 knockdown
InterventionPreclinical
1 paper studies it2 findings
Across all fields, 1 paper: none in people yet, 1 in animals
- 1 lab in 2 countries
- Funders: Japan Agency for Medical Research and Development and 4 more
- Animals1
Outcomes
2Energy expenditure
downin mice1
1 study
Energy expenditure
downin mice1
SLC12A8 knockdown decreases energy expenditure in mice.
“LH-specific knockdown of Slc12a8 in young mice decreases activity-dependent energy and carbohydrate expenditure”
Animalslateral hypothalamus
Cell reports
Muscle force
downin mice1
1 study
Muscle force
downin mice1
SLC12A8 knockdown decreases muscle force in mice.
“LH-specific knockdown of Slc12a8 in young mice decreases activity-dependent energy and carbohydrate expenditure and skeletal muscle functions, including muscle mass, muscle force, intramuscular glycolysis, and protein synthesis.”
Animalslateral hypothalamus
Cell reports
Latest
Cell Reports
Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
Experiments in miceMuscle