SALTE1
1 paper3 findings
- 1 lab in 1 country
- Funders: American Heart Association and 3 more
- Animals1
Effects
3Diastolic function
downin mice1
1 study
Diastolic function
downin mice1
SALTE1 impairs diastolic function in mice.
“In 20-month-old mice, SALTe1 inhibition, via antisense GapmeRs or EC-specific deletion, attenuated endothelial senescence, restored microvascular perfusion, and improved diastolic function.”
AnimalsShown by antisense GapmeR inhibition or endothelial-cell-specific deletionheart
Long noncoding RNA SALTe1, microvascular ageing, and cardiac dysfunction
European heart journal19 May 2026
Microvascular perfusion
downin mice1
1 study
Microvascular perfusion
downin mice1
SALTE1 impairs microvascular perfusion in mice.
“In 20-month-old mice, SALTe1 inhibition, via antisense GapmeRs or EC-specific deletion, attenuated endothelial senescence, restored microvascular perfusion, and improved diastolic function.”
AnimalsShown by antisense GapmeR inhibition or endothelial-cell-specific deletion
Long noncoding RNA SALTe1, microvascular ageing, and cardiac dysfunction
European heart journal19 May 2026
endothelial senescence
upin mice1
1 study
endothelial senescence
upin mice1
SALTE1 increases endothelial senescence in mice.
“In 20-month-old mice, SALTe1 inhibition, via antisense GapmeRs or EC-specific deletion, attenuated endothelial senescence, restored microvascular perfusion, and improved diastolic function.”
AnimalsShown by antisense GapmeR inhibition or endothelial-cell-specific deletionendothelial cell
Long noncoding RNA SALTe1, microvascular ageing, and cardiac dysfunction
European heart journal19 May 2026