RUBCN
- 1 lab in 1 country
- Funders: Core Research for Evolutional Science and Technology and 7 more
- 2 of 3 findings with company ties
- Animals1
- Model organisms1
Interventions
1Caloric restriction
downin mice1
1 study
Caloric restriction
downin mice1
Caloric restriction decreases RUBCN in mice.
“Rubicon is suppressed in several long-lived worms and calorie restricted mice”
Animalsin mice
Suppression of autophagic activity by Rubicon is a signature of aging
Nature communications19 Feb 2019
Effects
3exosome secretion
mediatesin reviews1
1 study
exosome secretion
mediatesin reviews1
RUBCN mediates exosome secretion.
“RUBCN/rubicon regulates exosome secretion through endosomal recruitment of WIPI2, which promotes ESCRT-dependent MVB formation.”
Reviewthrough endosomal recruitment of WIPI2
Rubicon regulates exosome secretion via the non-autophagic pathway
Autophagy12 Dec 2024
Exosome release
is required forin mice1
1 study
Exosome release
is required forin mice1
RUBCN is required for exosome release in mice.
“Rubicon is required for an age-dependent increase of exosome release in mice.”
Animalsage-dependent increase
The Rubicon-WIPI axis regulates exosome biogenesis during aging
bioRxiv (Cold Spring Harbor Laboratory)10 May 2024Preprint
WIPI2d recruitment to endosomes
upin mouse cells1
1 study
WIPI2d recruitment to endosomes
upin mouse cells1
RUBCN induces WIPI2d recruitment to endosomes in mouse cells.
“Rubicon recruits WIPI2d to endosomes to promote exosome biogenesis.”
Cells
The Rubicon-WIPI axis regulates exosome biogenesis during aging
bioRxiv (Cold Spring Harbor Laboratory)10 May 2024Preprint