AgingResearch.NewsJoin free

RTG2

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: European Molecular Biology Organization and 4 more
  • 2 of 2 findings with company ties
  • Cells1

Effects

1

Protein aggregates

downin yeast cells1is required forin yeast cells1

1 study

  1. RTG2 decreases protein aggregates in yeast cells.

    “Constitutive activation of retrograde signaling through overexpression of RTG2 or deletion of MKS-1, a negative regulator of Rtg1-Rtg3 nuclear translocation, resulted in faster resolution of aggregates upon heat shock”

    Cellsheat shock

    Perturbations in L-serine metabolism regulate protein quality control through the sensor of the retrograde response pathway RTG2 in Saccharomyces cerevisiae

    The Journal of biological chemistry31 May 2025

  2. RTG2 is required for protein aggregates in yeast cells.

    “Aggregate formation in the cha4Δ strain required a functional sensor of mitochondrial dysfunction and an activator of the retrograde signaling gene, RTG2.”

    Cellsin cha4Δ strain

    Perturbations in L-serine metabolism regulate protein quality control through the sensor of the retrograde response pathway RTG2 in Saccharomyces cerevisiae

    The Journal of biological chemistry31 May 2025

More on Protein aggregates

Latest

Related