There are 2 papers on rpn-10 in aging research: none in people yet, 2 in animals.
At a glance
The findings reach worms or flies, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
Worms or flies: a single group. Cells, mice and humans: nothing yet.
- 1 lab in 1 country
- Funders: Glenn Foundation for Medical Research and 6 more
- Model organisms2
Effects
2ATZ reporter accumulation
downin worms1
1 study
ATZ reporter accumulation
downin worms1
rpn-10 decreases ATZ reporter accumulation in rpn-10 mutant C. elegans alpha-1 antitrypsin deficiency model.
“The rpn-10 mutant shows a significant reduction in the accumulation of the ATZ reporter, thus indicating that its ER proteostasis is augmented”
Model organismsin rpn-10 mutant C. elegans alpha-1 antitrypsin deficiency modelintestine
Biochimica et biophysica acta. Gene regulatory mechanisms
ER unfolded protein response
upin worms1
1 study
ER unfolded protein response
upin worms1
rpn-10 activates ER unfolded protein response in worms (unstressed conditions).
“Under unstressed conditions, the ER unfolded protein response (UPR) is activated in the rpn-10 mutant as signified by increased xbp-1 splicing”
Model organismsunstressed conditions
Biochimica et biophysica acta. Gene regulatory mechanisms
Latest
Biochimica et Biophysica Acta Gene Regulatory Mechanisms
A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant
Experiments in wormsUbiquitin–proteasome system