RNASEL
- 1 lab in 1 country
- Funders: American Federation for Aging Research and 2 more
- Animals2
Effects
1Lifespan
downin mice1−32% survival / lifespan
1 study
Lifespan
downin mice1−32% survival / lifespan
RNASEL shortens lifespan in mice (-31.7% survival / lifespan).
“RNase-L-/- mice survived 31.7% (P<0.0001) longer than strain-matched RNase-L+/+ mice providing evidence for a physiological role for RNase-L in aging.”
Animalsshown by knockout
Role of 2-5A-dependent RNase-L in senescence and longevity
Oncogene20 Nov 2006
Latest
The American Journal of Pathology
Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities
Experiments in miceUbiquitin–proteasome system
Oncogene
Role of 2-5A-dependent RNase-L in senescence and longevity
Experiments in miceCellular senescence