RGR

There are 3 papers on RGR in aging research: none in people yet, 2 in animals, 1 in cells. The newest story, Nov 10, 2026: “A protein eased harm from its misfolded form in lab-grown eye cells”.

Gene

3 papers study it2 findings

HGNCNCBI GeneTaxon

See all 3 papers on RGR

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.
  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 3 more
  • Animals2
  • Cells1

Effects

2

Bruch's membrane thickening

downin mice1

1 study
  1. RGR protects against bruch's membrane thickening in mice (shown by deletion, with high-fat diet).

    “Transmission electron microscopy revealed a thickened Bruch's membrane along the choriocapillaris endothelial cell wall in the RGR-d + HFD mice”

    Animalsshown by deletion, with high-fat dietBruch's membrane

    Retinal G-protein-coupled receptor deletion exacerbates AMD-like changes via the PINK1-parkin pathway under oxidative stress

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Photoreceptor apoptosis

upin mice1

1 study
  1. RGR induces photoreceptor apoptosis in mice (homozygous RGR-d mice).

    “Aged RGR-d mice manifest disrupted RPE cell integrity, apoptotic photoreceptors, choroidal deposition of complement C3, and CD86+CD32+ proinflammatory cell infiltration into retina and RPE-choroid.”

    Animalshomozygous RGR-d mice

    Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin Contributes to the Pathogenesis of Age-Related Macular Degeneration

    Investigative ophthalmology & visual science

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months
Experimental Eye Research

A protein eased harm from its misfolded form in lab-grown eye cells

In experiments with lab-grown retinal cells, the normal protein bound its misfolded variant and reduced disruption of the cells’ protein-handling systems.In experiments with lab-grown retinal cells, the normal protein bound its misfolded variant and reduced disruption of the cells’ protein-handling systems.

Human cell studyEye