PTPA

1. PTPA increases carboplatin response in human cells.

   “Finally, PTPA restoration sensitized MPM cells to carboplatin as the likely consequence of lethal stress induction.”

   Cellsin PTPA-low human MPM cells

   Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells

   Cellular oncology (Dordrecht, Netherlands)·Jun 8, 2026

1. PTPA induces cellular senescence in human cells.

   “revealed increased RAS pathway activation, activated p53 signaling and induction of senescence (SA-β-Galactosidase, SASP, NF-κB activation) upon PTPA restoration”

   Cellsupon PTPA restoration in human MPM cells

   Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells

   Cellular oncology (Dordrecht, Netherlands)·Jun 8, 2026

More on Cellular senescence

1. PTPA decreases anchorage-independent cell growth in human cells.

   “Re-expression of PTPA in PTPA-low human MPM cells decreased 2D colony formation and anchorage-independent cell growth”

   Cellsin PTPA-low human MPM cells

   Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells

   Cellular oncology (Dordrecht, Netherlands)·Jun 8, 2026

1. PTPA is associated with overall survival in humans (26%).

   “heterozygous loss of PTPA (PPP2R4), encoding the PP2A activator PTPA, occurred in 26% of MPM patients (TCGA, n = 87), correlating with significantly decreased overall survival.”

   HumansTCGA MPM cohortn = 87

   Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells

   Cellular oncology (Dordrecht, Netherlands)·Jun 8, 2026