PSME4

Gene

1 paper3 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funder: Natural Science Foundation of Beijing Municipality

Animals1

Effects

Lung tumor burden

upin mice1

1 study

PSME4 increases lung tumor burden in mice.
“In the urethane-induced mouse lung tumor model, PA200 ablation markedly reduces tumor burden, especially in middle-aged mice.”
Animalsurethane-induced lung tumors; shown by PA200 ablationlung
Removing a protein reduced lung tumour burden in mice
International journal of molecular sciences30 Sep 2026

β-catenin proteasomal degradation

upin cells1

1 study

PSME4 increases β-catenin proteasomal degradation in cells.
“Reciprocally, PA200 facilitates proteasomal degradation of β-catenin, thereby sustaining p53 activity and forming a negative feedback loop.”
Cells
Removing a protein reduced lung tumour burden in mice
International journal of molecular sciences30 Sep 2026

Associations

Poor lung cancer prognosis

upin humans1

1 study

PSME4 is associated with poor lung cancer prognosis in humans.
“Elevated PA200 correlates with poor prognosis and advancing age in human lung cancer.”
Humanslung cancerlung
Removing a protein reduced lung tumour burden in mice
International journal of molecular sciences30 Sep 2026

Latest

1 in 12 months

International Journal of Molecular Sciences5 h

Removing a protein reduced lung tumour burden in mice

An animal experiment found that mice lacking the protein PA200 had reduced chemically induced lung tumour burden, especially in middle age.An animal experiment found that mice lacking the protein PA200 had reduced chemically induced lung tumour burden, especially in middle age.

Experiments in mice with chemically induced lung tumoursLung

Limit: Whether a PA200-targeting treatment benefits older patients was not tested

Paper

PSME4

Effects

Associations

Latest

Removing a protein reduced lung tumour burden in mice

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