PRKAG3

6 papers study it2 findings

HGNC NCBI Gene Taxon

None of its findings points the other way.

2 independent labs in 1 country

Funders: National Institute on Aging and 5 more
1 of 2 findings with company ties

Human trial1
Humans2
Animals3

Associations

1

Physical function

downin humans2

2 studies

PRKAG3 is associated with physical function in humans.
“expression of WDR59 and WDR24, both subunits of GATOR2 complex (an indirect inhibitor of mTORC1), and PRKAG3, which is a regulatory subunit of AMPK, were negatively correlated with multiple outcomes.”
Humansskeletal muscle
Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA)
Aging cellApr 16, 2024
PRKAG3 is associated with physical function in humans.
“expression of WDR59 and WDR24, both subunits of GATOR2 complex (an indirect inhibitor of mTORC1) and PRKAG3, which is a regulatory subunit of AMPK, were negatively correlated with multiple outcomes.”
Humansskeletal musclen = 575
Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the Study of Muscle, Mobility and Aging (SOMMA)
medRxiv : the preprint server for health sciencesNov 5, 2023Preprint

Latest

1 paper in 12 months

Experimental GerontologyJun 24

Calorie restriction and exercise differentially regulate AMP-activated protein kinase across subcellular compartments in skeletal muscle from older male rats

Experiments in ratsDietary restriction

Aging CellApr 17

Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA)

Cohort study of 575 peopleOxidative phosphorylation

medRxivApr 16

Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the Study of Muscle, Mobility and Aging (SOMMA)

Preprint: cohort study of 575 peopleOxidative phosphorylation

The Journals of Gerontology, Series AOct 22

Greater Phosphorylation of AMPK and Multiple AMPK Substrates in the Skeletal Muscle of 24-Month-Old Calorie Restricted Compared to Ad-Libitum Fed Male Rats

Experiments in ratsDietary restriction

The Journal of PhysiologyJan 24

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle

Non-randomized trial in 17 peopleMuscle

Mechanisms of Ageing and DevelopmentDec 27

Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats

Experiments in ratsDietary restriction