PLD1

There are 7 papers on PLD1 in aging research: none in people yet, 6 in animals, 1 in cells.

7 papers study it2 findings

HGNC NCBI Gene Taxon

See all 7 papers on PLD1

At a glance

The findings reach mice, none yet in people. 2 independent labs in 2 countries.

None of its findings points the other way.

2 independent labs in 2 countries

Funder: National Natural Science Foundation of China

Animals6
Cells1

Effects

2

Synaptic transmission

downin mice1

1 study

PLD1 impairs synaptic transmission in mice (aged WT mice).
“electrophysiological studies revealed PLD1 OXP impaired long-term potentiation (LTP) and synaptic transmission, particularly in aged WT mice”
Animalsaged WT mice
PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis
bioRxiv : the preprint server for biologyDec 11, 2025Preprint

More on Synaptic transmission

osteogenic differentiation

is required forin mouse cells1

1 study

PLD1 is required for osteogenic differentiation in mouse cells (shown by VU0359595 blockade).
“Blocking PLD1 with VU0359595 reversed these effects.”
Cellsshown by VU0359595 blockadebone marrow mesenchymal stem cells
Segetalin B promotes bone formation in ovariectomized mice by activating PLD1/SIRT1 signaling to inhibit γ-secretase-mediated Notch1 overactivation
The Journal of steroid biochemistry and molecular biologyDec 28, 2024

Latest

3 papers in 12 months

Research SquareAug 3

Encoding Intermittent Parathyroid Hormone Signals in Stem Cell Exosomes Enables Targeted Repair of Osteoporotic Bone Defects

Preprint: experiments in ratsOsteoporosis

bioRxivMar 4

PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis

Preprint: experiments in miceSynapse

MedCommFeb 3

HSD17B7 Counters Bone Loss in Estrogen Deficiency via Estrogen Receptor Stabilization and Mediates the Effect of Raloxifene

Experiments in miceBones and joints

Cell & BioscienceApr 17

Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling

Experiments in cellsNicotinamide mononucleotide

The Journal of Steroid Biochemistry and Molecular BiologyDec 31

Segetalin B promotes bone formation in ovariectomized mice by activating PLD1/SIRT1 signaling to inhibit γ-secretase-mediated Notch1 overactivation

Experiments in miceBones and joints

Poultry ScienceFeb 1

Transcriptome analysis and identification of age-associated fertility decreased genes in hen uterovaginal junction

Experiments in chickensReproductive system

Journal of Cachexia, Sarcopenia and MuscleFeb 15

Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice

Experiments in miceDocosahexaenoic acid