PIRB
Gene1 paper1 finding
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.
A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.
- Animals1
Effects
1PI3K/AKT phosphorylation
is required forin mouse cells1
1 study
PI3K/AKT phosphorylation
is required forin mouse cells1
PIRB is required for PI3K/AKT phosphorylation in mouse cells.
Cellsrequired for inhibition by recombinant ANGPTL8; shown by PirB knockdown
A metabolic protein promotes blood stem cell aging in mice · Biogerontology · 8 Oct 2026
Latest
1A metabolic protein promotes blood stem cell aging in mice
In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.