ANGPTL8
Gene1 paper2 findingsHGNC 24933NCBI Gene 55908Taxon 9606
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.
A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.
- Animals1
Effects
2PI3K–AKT signalling
downin mouse cells1
1 study
PI3K–AKT signalling
downin mouse cells1
ANGPTL8 inhibits PI3K–AKT signalling in mouse cells.
Cellsshown by ANGPTL8 deficiency
A metabolic protein promotes blood stem cell aging in mice · Biogerontology · 8 Oct 2026
Senescence-associated phenotypes
upin mice1
1 study
Senescence-associated phenotypes
upin mice1
ANGPTL8 increases senescence-associated phenotypes in mice.
Animalsshown by systemic ANGPTL8 knockoutmultiple tissues
A metabolic protein promotes blood stem cell aging in mice · Biogerontology · 8 Oct 2026
Latest
1A metabolic protein promotes blood stem cell aging in mice
In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.