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PEPCK

There are 4 papers on PEPCK in aging research: none in people yet, 4 in animals.

Gene

4 papers study it2 findings

HGNCNCBI GeneTaxon

See all 4 papers on PEPCK

At a glance

The findings reach worms or flies, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Howard Hughes Medical Institute and 1 more
  • Model organisms4

Effects

1

Copulatory behavior

upin worms1

1 study

  1. PEPCK improves copulatory behavior in mid-aged males.

    “in mid-aged males, gluco-/glyceroneogenesis, promoted by phosphoenolpyruvate carboxykinase (PEPCK), sustains competitive reproductive behavior”

    Model organismsin mid-aged malesmales

    Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males

    iScience

Associations

1

egl-2

downin worms1

1 study

  1. PEPCK is associated with egl-2 in worms (insufficient PEPCK expression).

    “Insufficient PEPCK expression correlates with reduced egl-2-encoded ether-a-go-go K+ channel expression”

    Model organismsinsufficient PEPCK expression

    Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males

    iScience

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