PELI1
- 2 independent labs in 2 countries
- Funders: National Natural Science Foundation of China and 2 more
- Animals2
- Cells1
Effects
5Body weight
upin mice1
1 study
Body weight
upin mice1
PELI1 increases body weight in mice.
“conditional Knockout (cKO) of Pellino-1 in 6-week-old mice resulted in decreased bone mass, reduced body size, and lower weight than in Pellino-1 floxed mice”
Animalsshown by conditional knockout compared with Pellino-1 floxed mice; differences absent at 20 weeks
Age-Related Decrease in Pellino-1 Expression Contributes to Osteoclast-Mediated Bone Loss
Advanced biologyMay 7, 2024
Bone mass
upin mice1
1 study
Bone mass
upin mice1
PELI1 increases bone mass in mice.
“conditional Knockout (cKO) of Pellino-1 in 6-week-old mice resulted in decreased bone mass, reduced body size, and lower weight than in Pellino-1 floxed mice”
Animalsshown by conditional knockout compared with Pellino-1 floxed mice; differences absent at 20 weeksbone
Age-Related Decrease in Pellino-1 Expression Contributes to Osteoclast-Mediated Bone Loss
Advanced biologyMay 7, 2024
Inflammation
upin mice1
1 study
Inflammation
upin mice1
PELI1 increases inflammation in mice.
“silencing Pellino-1 could inhibit COPD and inflammation via reduction of SASPs regulated by p21.”
AnimalsCOPD mouse model; shown by silencing Pellino-1lung
PreprintJun 29, 2022
Chronic obstructive pulmonary disease
upin mice1
1 study
Chronic obstructive pulmonary disease
upin mice1
PELI1 increases chronic obstructive pulmonary disease in mice.
“silencing Pellino-1 could inhibit COPD and inflammation via reduction of SASPs regulated by p21.”
AnimalsCOPD mouse model; shown by silencing Pellino-1lung
PreprintJun 29, 2022
lung cellular senescence
upin mouse cells1
1 study
lung cellular senescence
upin mouse cells1
PELI1 increases lung cellular senescence in mouse cells.
“p21-mediated lung cellular senescence could be inhibited by silencing Pellino-1.”
Cellsshown by silencing Pellino-1lung
PreprintJun 29, 2022