HMGB1

Exercise prevents doxorubicin-induced cardiac senescence in mice

In transgenic mice, exercise prevented doxorubicin-induced cardiotoxicity and senescence while maintaining cardiac FNDC5 levels, with irisin blunting…In transgenic mice, exercise prevented doxorubicin-induced cardiotoxicity and senescence while maintaining cardiac FNDC5 levels, with irisin blunting senescence in cultured human cells.