There are 3 papers on NOX4EXPRESSION in aging research: none in people yet, 3 in animals.
3 papers study it3 findings
See all 3 papers on NOX4EXPRESSION
At a glance
The findings reach mice, none yet in people. 3 independent labs in 3 countries.
None of its findings points the other way.
- 3 independent labs in 3 countries
- Funders: National Heart, Lung, and Blood Institute and 7 more
- Animals3
Interventions
1Hs-n
downin mice1
1 study
Hs-n
downin mice1
Hs-n decreases NOX4EXPRESSION in mice.
“accompanied by reduced renal NOX4 expression”
Animalskidney
ACS applied materials & interfaces
Upstream
2Age
upin mice1
1 study
Age
upin mice1
Age increases NOX4EXPRESSION in mice (aged aorta vs young aorta).
“In an aged aorta, the expression of Nox4 mRNA and protein by Nox family of genes was markedly increased compared with a young aorta.”
Animalsaged aorta vs young aortaaorta
The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction
Redox biology
BRD4
is required forin mouse cells1
1 study
BRD4
is required forin mouse cells1
BRD4 is required for NOX4EXPRESSION in mouse cells.
“BET inhibition interferes with the association of Brd4, p300, and acetylated histone H4K16 with the Nox4 promoter in lung fibroblasts stimulated with the profibrotic cytokine, TGF-β1.”
CellsTGF-β1-stimulated lung fibroblasts; BET inhibition disrupted Brd4, p300, and acetylated H4K16 association with the Nox4 promoterlung fibroblast
Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice
JCI insight