Nepl15

1. Nepl15 decreases oxidative stress and ROS signalling in flies.

   “female mutants displayed reduced oxidative stress, elevated Sod2 expression, and increased ATP levels”

   Model organismsshown by gene deletionfemales

   Drosophila melanogaster Nepl15 gene deletion promotes anti-aging and anti-obesity phenotypes in a sex-dependent manner

   bioRxiv : the preprint server for biology·14 Jul 2026Preprint

More on Oxidative stress and ROS signalling

1. Nepl15 improves locomotor performance in flies.

   “Both sexes demonstrated improved locomotor performance, exercise endurance, gut barrier integrity, and preserved heart rate during progressive aging.”

   Model organismsshown by knockout mutation

   Drosophila melanogaster Nepl15 gene deletion promotes anti-aging and anti-obesity phenotypes in a sex-dependent manner

   bioRxiv : the preprint server for biology·14 Jul 2026Preprint

1. Nepl15 extends lifespan in flies.

   “mutant females, but not males, exhibited significantly extended lifespan.”

   Model organismsshown by gene deletionfemales

   Drosophila melanogaster Nepl15 gene deletion promotes anti-aging and anti-obesity phenotypes in a sex-dependent manner

   bioRxiv : the preprint server for biology·14 Jul 2026Preprint