MPST
- 2 independent labs in 2 countries
- Funders: Canada Research Chairs and 3 more
- Animals6
- In silico1
Interventions
1Methionine restriction
upin rats1
1 study
Methionine restriction
upin rats1
Methionine restriction increases MPST in rats.
“hepatic mercaptopyruvate-sulphur-transferase (MPST) activity also increased in response to MR.”
Animalsliver8 weeks
Mechanisms of ageing and development25 Oct 2018
Associations
1Hydrogen sulphide production
upin mice1
1 study
Hydrogen sulphide production
upin mice1
Hydrogen sulphide production is associated with MPST in mice.
“Increased hepatic H2S production in TejJ89 mice was associated with elevation of the mitochondrial H2S-producing enzyme 3-mercaptopyruvate sulfurtransferase (MPST).”
Animalsin TejJ89 mice under 40% DRliverfemales
GeroScience11 Mar 2020
Latest
1 in 12 monthsJournal of Molecular Evolution
Cystathionine Gamma-Lyase: A Potential Longevity Gene Under Selection?
Computational studyMechanisms
Journal of Physiological Investigation
Age- and Urothelium-related Changes in Hydrogen Sulfide-induced Responses in Mouse Bladder
Experiments in animalsMechanisms
Bioscience Reports
Asynchronous changes of hydrogen sulfide and its generating enzymes in most tissues with the aging process
Experiments in miceMechanisms
Redox Biology
Loss of cardiac mitochondrial complex I persulfidation impairs NAD⁺ homeostasis in aging
Experiments in miceMitochondrion
Mechanisms of Ageing and Development
Methionine restriction leads to hyperhomocysteinemia and alters hepatic H₂S production capacity in Fischer-344 rats
Experiments in ratsDietary restriction