MIR214

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs in 2 countries

Funders: Inha University and 5 more

Animals2

Effects

4

Hypertension

upin mice1

1 study

MIR214 increases hypertension in mice.
“This phenotype is alleviated in mice lacking Redd1, EC-specific Redd1, or miR-214-3p, and in mice expressing Redd1KK219/220AA”
Animalsshown by knockout or mutation in obese micemales
The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
Nature communications12 Mar 2026

More on Hypertension

SIRT1

downin mouse cells1

1 study

MIR214 decreases SIRT1 in mouse cells.
“These miRNAs suppress endothelial nitric oxide synthase (eNOS) and SIRT1 expression in human and mouse ECs.”
Cellsin human and mouse ECs
The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
Nature communications12 Mar 2026

NOS3

downin mouse cells1

1 study

MIR214 decreases NOS3 in mouse cells.
“These miRNAs suppress endothelial nitric oxide synthase (eNOS) and SIRT1 expression in human and mouse ECs.”
Cellsin human and mouse ECs
The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
Nature communications12 Mar 2026

Wnt/β-catenin signalling

downin mouse cells1

1 study

MIR214 inhibits wnt/β-catenin signalling in mouse cells.
“this microRNA suppresses the Wnt/β-catenin pathway by directly targeting the gene encoding β-catenin”
Cells
Aged Small Intestine Derived Small Extracellular Vesicles miR-214-3p Leads to Intermuscular Fatty Infiltration Through Wnt/β-Catenin Mediated Fibro-Adipogenic Progenitors Adipogenesis
FASEB journal : official publication of the Federation of American Societies for Experimental Biology3 Feb 2026

More on Wnt/β-catenin signalling

Latest

2 in 12 months

Nature Communications13 Mar

The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension

Experiments in miceSirtuin signalling

FASEB Journal3 Feb

Aged Small Intestine Derived Small Extracellular Vesicles miR-214-3p Leads to Intermuscular Fatty Infiltration Through Wnt/β-Catenin Mediated Fibro-Adipogenic Progenitors Adipogenesis

Experiments in miceWnt/β-catenin signalling