There are 8 papers on MIR124 in aging research: 2 observational studies in people, 1 in animals, 3 in cells, 1 review.
8 papers study it7 findings
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country.
“the increase in miR-124 levels in senescent facial skin was statistically significant”
None of its findings points the other way.
- 1 lab in 1 country
- Funder: Japan Society for the Promotion of Science
- Humans2
- Animals1
- Cells3
- In silico1
Interventions
1Ultraviolet radiation
upin human cells1
1 study
Ultraviolet radiation
upin human cells1
Ultraviolet radiation increases MIR124 in human cells (UVB-irradiated normal human epidermal keratinocytes).
“The expression of miR-124 increased in UVB-irradiated NHEKs compared to controls in a dose-dependent manner.”
CellsUVB-irradiated normal human epidermal keratinocytes
Bioscience trends
Effects
4VDR
downin silico1
1 study
VDR
downin silico1
MIR124 inhibits VDR in silico (predicted by in silico 3' UTR target analysis).
“miR-124-3p.1 and miR-124-3p.2 targets 3' UTR of VDR and SIRT1 genes”
In silicopredicted by in silico 3' UTR target analysis
Aging medicine (Milton (N.S.W))
SIRT1
downin silico1
1 study
SIRT1
downin silico1
MIR124 inhibits SIRT1 in silico (predicted by in silico 3' UTR target analysis).
“miR-124-3p.1 and miR-124-3p.2 targets 3' UTR of VDR and SIRT1 genes”
In silicopredicted by in silico 3' UTR target analysis
Aging medicine (Milton (N.S.W))
Squamous cell carcinoma
downin human cells1
1 study
Squamous cell carcinoma
downin human cells1
MIR124 decreases squamous cell carcinoma in human cells (overexpression by miR-124 mimic transfection in A431 cells).
“Forced overexpression of miR-124 as a result of the transfection of a miR-124 mimic in A431 resulted in the significant suppression of the proportion of cancer cells.”
Cellsoverexpression by miR-124 mimic transfection in A431 cells
Bioscience trends
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
MIR124 induces cellular senescence in human cells (overexpression by miR-124 mimic transfection in normal human epidermal keratinocytes).
“the number of NHEKs positive for senescence-associated β-galactosidase (SA-β-gal) increased significantly as a result of the overexpression of the miR-124 mimic”
Cellsoverexpression by miR-124 mimic transfection in normal human epidermal keratinocytes
Bioscience trends
Associations
2Squamous cell carcinoma
downin human cells1
1 study
Squamous cell carcinoma
downin human cells1
MIR124 is associated with squamous cell carcinoma in human cells (A431 squamous cell carcinoma cell line compared to normal human epidermal keratinocytes).
“Expression of miR-124 in A431, a human cutaneous squamous cell carcinoma (SCC) cell line, decreased significantly compared to that in NHEKs.”
CellsA431 squamous cell carcinoma cell line compared to normal human epidermal keratinocytes
Bioscience trends
Skin senescence
upin humans1
1 study
Skin senescence
upin humans1
MIR124 is associated with skin senescence in humans.
“the increase in miR-124 levels in senescent facial skin was statistically significant”
Humansskin
Bioscience trends