There are 6 papers on MIR-34A-5P in aging research: none in people yet, 4 in animals, 1 in cells, 1 review.
6 papers study it9 findings
See all 6 papers on MIR-34A-5P
At a glance
The findings reach mice, none yet in people; independent labs found the same change in cells. 5 independent labs in 1 country.
None of its findings points the other way.
- 5 independent labs in 1 country
- Funders: National Natural Science Foundation of China and 6 more
- Animals4
- Cells1
Interventions
1Moderate-intensity intermittent training
downin rats1
1 study
Moderate-intensity intermittent training
downin rats1
Moderate-intensity intermittent training decreases MIR-34A-5P in D-gal-induced aging rats.
“MIIT reduced this overexpression.”
Animalsin D-gal-induced aging ratsprefrontal cortex8 weeks
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Effects
6Cellular senescence
upin human cells1upin rat cells1
2 studies
Cellular senescence
upin human cells1upin rat cells1
MIR-34A-5P increases cellular senescence in rat cells (miR-34a-5p overexpression reversed quercetin protection in TBHP-treated cells).
“the protective effects of Que on cell senescence were partially reversed by miR-34a-5p overexpression and SIRT1 knockdown”
CellsmiR-34a-5p overexpression reversed quercetin protection in TBHP-treated cells
World journal of stem cells
MIR-34A-5P increases cellular senescence in human cells (shown by miR-34a-5p inhibitor).
“The miR-34a-5p inhibitor inhibited the cell cycle senescence of HNPCs.”
Cellsshown by miR-34a-5p inhibitornucleus pulposus
Frontiers in cell and developmental biology
MARCHF8
downin human cells1
1 study
MARCHF8
downin human cells1
MIR-34A-5P decreases MARCHF8 in human cells (upregulated in senescence).
“miR-34a-5p upregulation in senescence inhibited MARCHF8 expression”
Cellsupregulated in senescence
Mechanisms of ageing and development
Parkin mitochondrial recruitment
downin human cells1
1 study
Parkin mitochondrial recruitment
downin human cells1
MIR-34A-5P decreases Parkin mitochondrial recruitment in HEK293 cells.
“prevents the mitochondrial recruitment of Parkin, attenuates ubiquitination and delays the clearance of damaged mitochondria”
Cellsin HEK293 cellsmitochondrion
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes
Life sciences
Mitophagy
downin human cells1
1 study
Mitophagy
downin human cells1
MIR-34A-5P inhibits mitophagy in HEK293 cells.
“Further results indicated that miR-34a-5p inhibits mitophagy process by reduction of PINK1.”
Cellsin HEK293 cells
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes
Life sciences
PINK1EXPRESSION
downin human cells1
1 study
PINK1EXPRESSION
downin human cells1
MIR-34A-5P decreases PINK1EXPRESSION in HEK293 cells, with binding to PINK1 3'UTR and CDS via the non-seed region.
“we discovered that miR-34a-5p suppresses PINK1 expression directly”
Cellsin HEK293 cells, with binding to PINK1 3'UTR and CDS via the non-seed regionmimics
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes
Life sciences
SIRT1
downin human cells1
1 study
SIRT1
downin human cells1
MIR-34A-5P inhibits SIRT1 in human cells.
“miR-34a-5p was predicted to interact with the SIRT1 mRNA.”
Cells
Frontiers in cell and developmental biology
Associations
1Age
upin mice1
1 study
Age
upin mice1
MIR-34A-5P is associated with age in mice.
“The level of miR-34a-5p was upregulated and the level of PINK1 mRNA was downregulated in brains of aged mice.”
Animalsbrainmales
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes
Life sciences