Moderate-intensity intermittent training

1. Moderate-intensity intermittent training increases NOTCH1 in rats.

   “It also up-regulated Notch1 and inhibited excessive apoptosis by regulating Bcl-2 and Bax expression.”

   Animalsin D-gal aging ratsprefrontal cortex8 weeks

   Moderate-Intensity Intermittent Training Inhibits miR-34a-5p to Reduce Prefrontal Cortex Apoptosis and Improve Cognitive Ability in Aging Rats Reduced by D-galactose

   bioRxiv (Cold Spring Harbor Laboratory)·23 Aug 2025Preprint

More on NOTCH1

1. Moderate-intensity intermittent training decreases miR-34a-5p in rats.

   “Aging caused an overexpression of miR-34a-5p in the prefrontal cortex. MIIT reduced this overexpression.”

   Animalsin D-gal aging ratsprefrontal cortex8 weeks

   Moderate-Intensity Intermittent Training Inhibits miR-34a-5p to Reduce Prefrontal Cortex Apoptosis and Improve Cognitive Ability in Aging Rats Reduced by D-galactose

   bioRxiv (Cold Spring Harbor Laboratory)·23 Aug 2025Preprint

More on miR-34a-5p

1. Moderate-intensity intermittent training decreases apoptosis in rats.

   “The exercise also improved the structure of the prefrontal cortex (PFC) and reduced apoptosis.”

   Animalsin D-gal aging ratsprefrontal cortex8 weeks

   Moderate-Intensity Intermittent Training Inhibits miR-34a-5p to Reduce Prefrontal Cortex Apoptosis and Improve Cognitive Ability in Aging Rats Reduced by D-galactose

   bioRxiv (Cold Spring Harbor Laboratory)·23 Aug 2025Preprint

More on Apoptosis

1. Moderate-intensity intermittent training improves spatial learning and memory in rats.

   “8 weeks of MIIT significantly slowed the decline in spatial learning and memory in D-gal aging rats.”

   Animalsin D-gal aging ratsprefrontal cortex8 weeks

   Moderate-Intensity Intermittent Training Inhibits miR-34a-5p to Reduce Prefrontal Cortex Apoptosis and Improve Cognitive Ability in Aging Rats Reduced by D-galactose

   bioRxiv (Cold Spring Harbor Laboratory)·23 Aug 2025Preprint