AgingResearch.NewsJoin free

MARCHF8

There is 1 paper on MARCHF8 in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it5 findings

HGNCNCBI GeneTaxon

See all 1 papers on MARCHF8

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Guangxi Key Research and Development Program and 3 more
  • Animals1

Effects

3

Atherosclerosis

downin mice1

1 study

  1. MARCHF8 decreases atherosclerosis in mice (shown by overexpression in high-fat diet-fed apoE-/- mice).

    “In vivo, MARCHF8 overexpression in high-fat diet-fed apoE-/- mice reduced plasma interleukin-6 levels and attenuated atherosclerosis progression.”

    Animalsshown by overexpression in high-fat diet-fed apoE-/- mice

    miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence

    Mechanisms of ageing and development

More on Atherosclerosis

IL-6

downin mice1

1 study

  1. MARCHF8 decreases IL-6 in mice (shown by overexpression in high-fat diet-fed apoE-/- mice).

    “In vivo, MARCHF8 overexpression in high-fat diet-fed apoE-/- mice reduced plasma interleukin-6 levels and attenuated atherosclerosis progression.”

    Animalsshown by overexpression in high-fat diet-fed apoE-/- mice

    miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence

    Mechanisms of ageing and development

More on IL-6

Cellular senescence

downin human cells1

1 study

  1. MARCHF8 decreases cellular senescence in human cells (shown by knockdown in young HUVECs).

    “Knockdown of MARCHF8 in young HUVECs induced endothelial senescence and impaired key endothelial functions”

    Cellsshown by knockdown in young HUVECs

    miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence

    Mechanisms of ageing and development

More on Cellular senescence

Upstream

1

MIR-34A-5P

downin human cells1

1 study

  1. MIR-34A-5P decreases MARCHF8 in human cells (upregulated in senescence).

    “miR-34a-5p upregulation in senescence inhibited MARCHF8 expression”

    Cellsupregulated in senescence

    miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence

    Mechanisms of ageing and development

More on MIR-34A-5P

Associations

1

Cellular senescence

downin human cells1

1 study

  1. MARCHF8 is associated with cellular senescence in senescent HUVECs.

    “MARCHF8 expression was significantly reduced in senescent HUVECs”

    Cellsin senescent HUVECs

    miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence

    Mechanisms of ageing and development

More on Cellular senescence

Latest

Related