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MIR-181A-5P

Gene

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Deutsche Forschungsgemeinschaft
  • Animals1

Effects

3

Fibroblast proliferation

downin human cells1

1 study

  1. MIR-181A-5P decreases fibroblast proliferation in human cells.

    “Inhibiting miR-181a-5p restored SIRT1 levels, increased proliferation, and alleviated senescence in HGPS fibroblasts, supporting its functional relevance in disease progression.”

    CellsHGPS fibroblasts; shown by miR-181a-5p inhibitionfibroblast

    Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome

    Diseases (Basel, Switzerland)4 Aug 2025

SIRT1

downin human cells1

1 study

  1. MIR-181A-5P decreases SIRT1 in human cells.

    “Inhibiting miR-181a-5p restored SIRT1 levels, increased proliferation, and alleviated senescence in HGPS fibroblasts, supporting its functional relevance in disease progression.”

    CellsHGPS fibroblasts; shown by miR-181a-5p inhibitionfibroblast

    Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome

    Diseases (Basel, Switzerland)4 Aug 2025

More on SIRT1

Cellular senescence

upin human cells1

1 study

  1. MIR-181A-5P increases cellular senescence in human cells.

    “Inhibiting miR-181a-5p restored SIRT1 levels, increased proliferation, and alleviated senescence in HGPS fibroblasts, supporting its functional relevance in disease progression.”

    CellsHGPS fibroblasts; shown by miR-181a-5p inhibitionfibroblast

    Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome

    Diseases (Basel, Switzerland)4 Aug 2025

More on Cellular senescence

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