MFAP4

1. MFAP4 increases arterial stiffness in mice (Ang II-treated, ex vivo, shown by knockout).

   “Increased efficacy of vasoconstrictors (phenylephrine, thromboxane) and reduced stiffness were observed in Ang II-treated Mfap4-/- mouse mesenteric arteries”

   AnimalsAng II-treated, ex vivo, shown by knockoutmesenteric artery

   MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension

   Hypertension (Dallas, Tex. : 1979)·Apr 2, 2024

2. MFAP4 showed no clear effect on arterial stiffness in mice (aging, shown by knockout).

   “MFAP4-deficiency reduces the elastin/collagen ratio in the aging resistance artery without affecting arterial stiffness.”

   Animalsaging, shown by knockoutmesenteric artery

   MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension

   Hypertension (Dallas, Tex. : 1979)·Apr 2, 2024

1. MFAP4 increases diastolic pressure in mice (Ang II infusion, shown by knockout).

   “MFAP4-deficient mice exhibited reduced diastolic pressure in Ang II-induced hypertension.”

   AnimalsAng II infusion, shown by knockout20 days

   MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension

   Hypertension (Dallas, Tex. : 1979)·Apr 2, 2024

1. MFAP4 showed no clear effect on lymphocyte count in mice (MFAP4 deficiency).

   “No differences were observed for lymphocyte numbers or splenic structure.”

   AnimalsMFAP4 deficiencyspleen

   The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life

   Cell and tissue research·Feb 22, 2016

More on Lymphocyte count

1. MFAP4 increases follicular dendritic cell count in mice (shown by MFAP4-deficient conditions).

   “in splenic tissue regenerating under MFAP4-deficient conditions, the number of FDCs is significantly decreased”

   Animalsshown by MFAP4-deficient conditionsspleen

   The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life

   Cell and tissue research·Feb 22, 2016

More on Follicular dendritic cell count

1. MFAP4 showed no clear effect on splenic development in mice (MFAP4 deficiency).

   “The development of splenic tissue is not disturbed in MFAP4-deficient mice.”

   AnimalsMFAP4 deficiencyspleen

   The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life

   Cell and tissue research·Feb 22, 2016