MCUB

Gene

2 papers study it3 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 2

None of its findings points the other way.

1 lab in 1 country

Funders: National Heart, Lung, and Blood Institute and 2 more

Animals2

Effects

Glucose intolerance

downin mice1

1 study

MCUB protects against glucose intolerance in mice.
“In contrast, mice lacking Mcub in skeletal muscle showed increased pyruvate dehydrogenase activity, increased muscle malonyl coenzyme A (CoA), reduced fatty acid utilization, glucose intolerance, and increased adiposity.”
Animalsshown by skeletal muscle-specific Mcub knockoutskeletal muscle
MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle
Cell reportsNov 16, 2023

Latest

1 paper in 12 months

Cardiovascular ResearchOct 25

A protein promotes an irregular heartbeat in animals

Animal experiments found that raising levels of the protein MAPK15 worsened heart muscle cell senescence and promoted atrial fibrillation, an irregular heartbeat.Animal experiments found that raising levels of the protein MAPK15 worsened heart muscle cell senescence and promoted atrial fibrillation, an irregular heartbeat.

Animal studyMechanisms

Paper

Cell ReportsNov 17

MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle

Experiments in miceLipid and ceramide metabolism