MCLK1

1. MCLK1 has no effect on lifespan in mice.

   “Furthermore, the absence of ApoE suppressed the lifespan-promoting effects of Mclk1 heterozygosity.”

   Animalsin ApoE-/- mice

   Mclk1+/- mice are not resistant to the development of atherosclerosis

   Lipids in health and disease·5 May 2009

1. MCLK1 has no effect on oxidative stress and ROS signalling in mice.

   “We found that Mclk1 heterozygosity did not protect against dyslipidemia, oxidative stress, or atherosclerosis in young (6 or 10 months) or older (18 months) mice.”

   Animalsin ApoE-/- or LDLr-/- mice fed atherosclerosis-inducing diet

   Mclk1+/- mice are not resistant to the development of atherosclerosis

   Lipids in health and disease·5 May 2009

More on Oxidative stress and ROS signalling

1. MCLK1 has no effect on dyslipidemia in mice.

   “We found that Mclk1 heterozygosity did not protect against dyslipidemia, oxidative stress, or atherosclerosis in young (6 or 10 months) or older (18 months) mice.”

   Animalsin ApoE-/- or LDLr-/- mice fed atherosclerosis-inducing diet

   Mclk1+/- mice are not resistant to the development of atherosclerosis

   Lipids in health and disease·5 May 2009

More on Dyslipidemia

1. MCLK1 has no effect on atherosclerosis in mice.

   “We found that Mclk1 heterozygosity did not protect against dyslipidemia, oxidative stress, or atherosclerosis in young (6 or 10 months) or older (18 months) mice.”

   Animalsin ApoE-/- or LDLr-/- mice fed atherosclerosis-inducing diet

   Mclk1+/- mice are not resistant to the development of atherosclerosis

   Lipids in health and disease·5 May 2009

More on Atherosclerosis