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KLK1

Gene

2 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1
  • In silico1

Effects

2

Smooth muscle cell/collagen ratio

upin rats1

1 study

  1. KLK1 increases smooth muscle cell/collagen ratio in rats.

    “compared with those of the yWTR and aTGR groups, the ratio of smooth muscle cell (SMC)/collagen (C) was significantly lower in the aWTR group.”

    Animalstransgenic rats harboring human KLK1 compared with aged wild-type ratscorpus cavernosummales

    Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1

    Asian journal of andrology

More on Smooth muscle cell/collagen ratio

Erectile function

upin rats1

1 study

  1. KLK1 improves erectile function in rats.

    “the erectile function of rats in the aWTR group was significantly lower than that of other two groups.”

    Animalstransgenic rats harboring human KLK1 compared with aged wild-type ratscorpus cavernosummales

    Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1

    Asian journal of andrology

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