ADK

5 papers study it3 findings

2 independent labs in 1 country

Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 2 more

Animals2
Cells2
In silico1

Effects

2

Glucose homeostasis

is required forin mice2

2 studies

ADK is required for glucose homeostasis in mice.
“ADK inhibition abolished these effects, confirming that NRH's direct entry into tissues and subsequent phosphorylation is essential for its full benefits.”
Animalsin NRH-treated diet-induced obese mice
NRH, a potent NAD⁺ enhancer, improves glucose homeostasis and lipid metabolism in diet-induced obese mice through an active adenosine kinase pathway
Metabolism: clinical and experimentalDec 20, 2024
ADK is required for glucose homeostasis in mice.
“suggesting an active ADK pathway is necessary for NRH-induced metabolic benefits.”
Animalsfor NRH-induced metabolic benefits
NRH, a potent NAD+ booster, improves glucose homeostasis and lipid metabolism in diet-induced obese mice though an active adenosine kinase pathway
bioRxiv (Cold Spring Harbor Laboratory)Aug 30, 2024Preprint

Intracellular ATP

upin cells1

1 study

ADK increases intracellular ATP in cells.
“The intracellular adenosine is converted to AMP by adenosine kinase, which increases the intracellular ATP levels”
Cellsbasal conditions; extracellular NAD+ degradation into adenosineBV2 microglia
Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD⁺-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions
Frontiers in cellular neuroscienceOct 18, 2018

More on Intracellular ATP

Latest

MetabolismDec 20

NRH, a potent NAD⁺ enhancer, improves glucose homeostasis and lipid metabolism in diet-induced obese mice through an active adenosine kinase pathway

Experiments in miceInterventions

bioRxivAug 30

NRH, a potent NAD+ booster, improves glucose homeostasis and lipid metabolism in diet-induced obese mice though an active adenosine kinase pathway

Preprint: experiments in miceMetabolic syndrome

Annals of Translational MedicineFeb 24

Identification of key genes, biological functions, and pathways of empagliflozin by network pharmacology and its significance in the treatment of type 2 diabetes mellitus

Computational studyMechanisms

Frontiers in ImmunologyFeb 25

Dihydronicotinamide Riboside Is a Potent NAD⁺ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages

Experiments in human cellsNAD+ precursors

Frontiers in Cellular NeuroscienceOct 18

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD⁺-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions

Experiments in cellsAMPK signaling