KAT7
- 2 independent labs in 1 country
- Funders: Beijing Municipal Science and Technology Commission and 1 more
- Animals2
- Cells1
Effects
2MCPH1 nuclear translocation
mediatesin mice1
1 study
MCPH1 nuclear translocation
mediatesin mice1
KAT7 mediates MCPH1 nuclear translocation in mice.
“KAT7-mediated lysine acetylation within the NLS motif of MCPH1 in response to DNA damage facilitates its nuclear translocation.”
Animalslysine acetylation within the MCPH1 NLS motif in response to DNA damagehematopoietic stem cell
Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function
Nature aging17 Apr 2024
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
KAT7 decreases cellular senescence in mice.
“lentiviral vectors encoding Cas9/sg-Kat7, given intravenously, alleviated hepatocyte senescence and liver aging”
Animalslentiviral Cas9/sg-Kat7 given intravenouslyliver
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
Science translational medicine6 Jan 2021
Latest
1 in 12 monthsNature Aging
Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function
Experiments in animalsBlood and immune system
Science Translational Medicine
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
Experiments in human cellsInterventions