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MCPH1

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Beijing Municipal Science and Technology Commission and 1 more
  • Animals1

Effects

2

Hematopoietic stem cell function

downin mice1

1 study

  1. MCPH1 impairs hematopoietic stem cell function in mice.

    “Aging triggers MCPH1 translocation from cytosol to nucleus, reducing its cytoplasmic retention and leading to the activation of necroptosis and deterioration of HSC function.”

    Animalsaging-induced MCPH1 translocation from cytosol to nucleushematopoietic stem cell

    Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function

    Nature aging17 Apr 2024

necroptosis

downin mice1

1 study

  1. MCPH1 prevents necroptosis in mice.

    “in the cytoplasm, it prevents necroptosis by binding with p-RIPK3.”

    Animalscytoplasmic MCPH1 binding to p-RIPK3hematopoietic stem cell cytoplasm

    Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function

    Nature aging17 Apr 2024

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