IL11RA1

3 papers2 findings

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals3

Effects

2

Ovarian function

downin mice1

1 study

IL11RA1 impairs ovarian function in mice.
“Genetic deletion of Il11ra1 in mice mitigated the increase in ovarian matrix stiffness and the decline in ovarian function associated with aging, chemotherapy-induced POI and PCOS.”
Animalsin aging, chemotherapy-induced POI and PCOSovary
Modulating IL-11-dependent matrix stiffness to delay ovarian aging
Nature aging2 Jul 2026

Ovarian matrix stiffness

upin mice1

1 study

IL11RA1 increases ovarian matrix stiffness in mice.
“Genetic deletion of Il11ra1 in mice mitigated the increase in ovarian matrix stiffness and the decline in ovarian function associated with aging, chemotherapy-induced POI and PCOS.”
Animalsin aging, chemotherapy-induced POI and PCOSovary
Modulating IL-11-dependent matrix stiffness to delay ovarian aging
Nature aging2 Jul 2026

More on Ovarian matrix stiffness

Latest

1 in 12 months

Nature Aging3 Jul

Modulating IL-11-dependent matrix stiffness to delay ovarian aging

Experiments in miceReproductive system

Nature17 Jul

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Experiments in miceInterventions

Journal of the American Society of Nephrology9 Feb

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome

Experiments in miceKidney