Ovarian matrix stiffness

1. IL11 increases ovarian matrix stiffness in human cells.

   “IL-11, which is elevated in aging ovaries of mice, rats and humans, activates fibroblasts to secrete extracellular matrix (ECM), thereby increasing ovarian matrix stiffness.”

   Cellsovary

   Modulating IL-11-dependent matrix stiffness to delay ovarian aging

   Nature aging·2 Jul 2026

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1. IL11RA1 increases ovarian matrix stiffness in mice.

   “Genetic deletion of Il11ra1 in mice mitigated the increase in ovarian matrix stiffness and the decline in ovarian function associated with aging, chemotherapy-induced POI and PCOS.”

   Animalsin aging, chemotherapy-induced POI and PCOSovary

   Modulating IL-11-dependent matrix stiffness to delay ovarian aging

   Nature aging·2 Jul 2026

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