Igf1

1. Igf1 decreases mitochondrial dysfunction in mouse cells.

   “IGF-1 deficiency suppressed SLC25A33 expression in vitro, leading to mitochondrial ROS (mtROS) accumulation”

   CellsIGF-1 deficiency in vitropericyte

   IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026

Mitochondrial dysfunction →

1. Igf1 is associated with age-related hearing loss in mice.

   “Transcriptomics revealed significant downregulation of Igf1 and Slc25a33 in aged pericytes, with enrichment of the TGF-β signaling pathway.”

   Animalspericyte

   IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026

Age-related hearing loss →