HTRA2

5 papers1 finding

HGNC NCBI Gene Taxon

1 lab in 1 country

Animals4
Cells1

Effects

1

Mortality

downin mice1

1 study

HTRA2 prevents mortality in mice.
“rescues htra2 (mnd2) mice from early onset neurodegeneration, and other phenotypic abnormalities and prevents their early death”
Animalsin htra2 (mnd2) mice
A novel role for the mitochondrial HTRA2/OMI protease in aging
Autophagy14 Dec 2012

Latest

2 in 12 months

Cellular Signalling25 Jul

Impaired mitochondrial quality control and stress signalling machinery modulate senescence induction by genotoxic challenge

Experiments in mouse cellsCellular senescence

Nature Metabolism9 Jul

Hypoxia rescues complex 1-associated disease caused by proteostatic defects

Experiments in miceInterventions

Autophagy14 Dec

A novel role for the mitochondrial HTRA2/OMI protease in aging

Experiments in miceMitochondrion

PLOS One19 Dec

Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice

Experiments in miceResveratrol

Aging Cell30 Oct

Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression

Experiments in miceInterventions