HMGB2

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs in 1 country

Animals3
Cells1

Effects

TNF-alpha

downin mouse cells1

1 study

HMGB2 inhibits TNF-alpha in mouse cells.
“HMGB2 promotes osteogenesis by directly suppressing TNF-α”
Cellsbone marrow
HMGB2 Deficiency in Bone Marrow Mesenchymal Stem Cells Promotes Age-Related Osteoporosis by Inhibiting Osteoblast Differentiation via Inflammatory Factors
FASEB journal : official publication of the Federation of American Societies for Experimental Biology13 Nov 2025

Associations

Osteoporosis

upin mice1

1 study

HMGB2 is associated with osteoporosis in mice.
“ovariectomy-induced aging mice revealed a strong correlation between HMGB2 downregulation and osteoporosis progression”
Animalsin ovariectomy-induced mice
HMGB2 Deficiency in Bone Marrow Mesenchymal Stem Cells Promotes Age-Related Osteoporosis by Inhibiting Osteoblast Differentiation via Inflammatory Factors
FASEB journal : official publication of the Federation of American Societies for Experimental Biology13 Nov 2025