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GSTA4

Gene

4 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Eye Institute
  • Animals4

Interventions

1

Osk reprogramming

upin mice1

1 study

  1. Osk reprogramming activates GSTA4 in mice.

    “GSTA4, a detoxifying enzyme that clears the lipid peroxidation byproduct 4-HNE, as a necessary and sufficient OSK effector.”

    Animalsin RPEretinal pigment epithelium

    Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

    bioRxiv : the preprint server for biology1 Sep 2025Preprint

More on Osk reprogramming

Effects

1

Visual function

upin mice1

1 study

  1. GSTA4 improves visual function in mice.

    “GSTA4 overexpression alone enhances mitochondrial resilience, rejuvenates the aged RPE transcriptome, and reverses visual decline.”

    Animalsoverexpression aloneretinal pigment epithelium

    Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

    bioRxiv : the preprint server for biology1 Sep 2025Preprint

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