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GHS-R

There are 3 papers on GHS-R in aging research: none in people yet, 3 in animals.

Gene

3 papers study it11 findings

See all 3 papers on GHS-R

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: BrightFocus Foundation and others
  • Animals3

Effects

10

Irisin

downin mice1

1 study

  1. GHS-R decreases irisin in mice (shown by knockout in old mice).

    “old GHS-R-ablated mice showed increased expression of the irisin precursor FNDC5 in the muscle and elevated plasma irisin levels in circulation”

    Animalsshown by knockout in old miceskeletal muscle

    Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle

    Genes

More on Irisin

Treadmill performance

downin mice1

1 study

  1. GHS-R impairs treadmill performance in mice (shown by knockout in old mice).

    “old Ghsr-/- mice showed improved treadmill performance, supporting better functionality.”

    Animalsshown by knockout in old mice

    Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle

    Genes

Metabolic profile of aging skeletal muscle

downin mice1

1 study

  1. GHS-R impairs metabolic profile of aging skeletal muscle in mice (shown by knockout in old mice).

    “Remarkedly the muscle of old GHS-R knockout (Ghsr-/-) mice exhibited a youthful metabolic profile and better maintenance of oxidative type 2 muscle fibers.”

    Animalsshown by knockout in old miceskeletal muscle

    Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle

    Genes

Tight junction marker expression

upin mice1

1 study

  1. GHS-R increases tight junction marker expression in mice (shown by knockout in DSS-induced acute colitis).

    “and decreased expression of tight junction markers”

    Animalsshown by knockout in DSS-induced acute colitis

    Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging

    International journal of molecular sciences

More on Tight junction marker expression

Proinflammatory cytokine expression

downin mice1

1 study

  1. GHS-R decreases proinflammatory cytokine expression in mice (shown by knockout in DSS-induced acute colitis).

    “The GHS-R KO mice showed more severe disease activity scores, higher proinflammatory cytokine expression”

    Animalsshown by knockout in DSS-induced acute colitis

    Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging

    International journal of molecular sciences

More on Proinflammatory cytokine expression

Disease activity score

downin mice1

1 study

  1. GHS-R decreases disease activity score in mice (shown by knockout in DSS-induced acute colitis).

    “The GHS-R KO mice showed more severe disease activity scores”

    Animalsshown by knockout in DSS-induced acute colitis

    Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging

    International journal of molecular sciences

Bacteroidetes

upin mice1

1 study

  1. GHS-R increases Bacteroidetes in mice (shown by knockout in aged mice).

    “aged GHS-R KO mice exhibited reduced Bacteroidetes and increased Firmicutes, featuring a disease-susceptible microbiome profile”

    Animalsshown by knockout in aged mice

    Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging

    International journal of molecular sciences

lipolysis

downin mouse cells1

1 study

  1. GHS-R decreases lipolysis in mouse cells (ex vivo, shown by GHS-R deficiency).

    “GHS-R deficient white adipocytes from old mice exhibit increased glucose uptake and lipolysis”

    Cellsex vivo, shown by GHS-R deficiencywhite adipocytes

    aP2-Cre Mediated Ablation of GHS-R Attenuates Adiposity and Improves Insulin Sensitivity during Aging

    International journal of molecular sciences

Insulin sensitivity

downin mice1

1 study

  1. GHS-R impairs insulin sensitivity in mice (shown by aP2-Cre-mediated knockdown).

    “Both young and old aP2-Cre/Ghsrf/f mice exhibited improved insulin sensitivity and glucose tolerance.”

    Animalsshown by aP2-Cre-mediated knockdown

    aP2-Cre Mediated Ablation of GHS-R Attenuates Adiposity and Improves Insulin Sensitivity during Aging

    International journal of molecular sciences

Body fat

upin mice1

1 study

  1. GHS-R increases body fat in mice (shown by aP2-Cre-mediated knockdown).

    “old mice showed pronounced reductions of both body weight and body fat”

    Animalsshown by aP2-Cre-mediated knockdown

    aP2-Cre Mediated Ablation of GHS-R Attenuates Adiposity and Improves Insulin Sensitivity during Aging

    International journal of molecular sciences

Associations

1

Metabolic function

downin mice1

1 study

  1. GHS-R is associated with metabolic function in mice during aging.

    “There was an increase of GHS-R expression in skeletal muscle during aging, inversely correlated with the decline of metabolic functions.”

    Animalsduring agingskeletal muscle

    Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle

    Genes

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