FKBPL

1. FKBPL increases NFE2L2 protein abundance in human cells.

   “FKBPL modulated the kelch-like ECH associated protein 1 (KEAP1)-associated ubiquitination and increased nuclear factor erythroid-related factor 2 (NRF2) protein abundance”

   Cellstriple-negative breast cancer

   Pharmacological targeting of FKBPL with rapamycin sensitizes triple-negative breast cancer to ferroptosis

   International journal of biological macromolecules·16 Oct 2026

More on NFE2L2 protein abundance

1. FKBPL increases tumor growth in humans.

   “FKBPL knockdown markedly impaired TNBC cell proliferation and migration in vitro and suppressed tumor growth in vivo.”

   Animalsshown by FKBPL knockdown

   Pharmacological targeting of FKBPL with rapamycin sensitizes triple-negative breast cancer to ferroptosis

   International journal of biological macromolecules·16 Oct 2026

1. FKBPL is associated with patient prognosis in humans.

   “FKBPL was significantly overexpressed in TNBC and correlated with inferior patient prognosis.”

   Humanstriple-negative breast cancer

   Pharmacological targeting of FKBPL with rapamycin sensitizes triple-negative breast cancer to ferroptosis

   International journal of biological macromolecules·16 Oct 2026