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FBLN7

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Animals1

Effects

2

Cardiac diastolic function

downin mice1

1 study

  1. FBLN7 impairs cardiac diastolic function in mice.

    “the cardioprotective effects observed in aged FBLN7 knockout (KO) mice are mediated by the inhibition of profibrotic phenotypes in senescent cardiac fibroblasts (CFs), which reduces age-related myocardial fibrosis and ultimately improves cardiac diastolic function.”

    Animalsshown by knockout

    FBLN7 KO attenuates age-related cardiac fibrosis by promoting TGFBR3/ALK1/Smad1 signaling and inhibiting the profibrotic phenotypes of cardiac fibroblasts

    Theranostics28 Jul 2025

Myocardial fibrosis

upin mice1

1 study

  1. FBLN7 increases myocardial fibrosis in mice.

    “The observation that overexpressing FBLN7 in fibroblast-specific protein 1 positive (FSP1+) cells of aged mice exacerbates age-related myocardial fibrosis further supports this finding.”

    Animalsin aged mice

    FBLN7 KO attenuates age-related cardiac fibrosis by promoting TGFBR3/ALK1/Smad1 signaling and inhibiting the profibrotic phenotypes of cardiac fibroblasts

    Theranostics28 Jul 2025

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